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It was revealed that separation of LCP with early LC (n=215) from invasive LCP (n=555) significantly depended on: Hb, leucocytes (abs, total), thrombocytes (abs, tot), erythrocytes (abs, tot), segmented neutrophils (%, abs, total), stick neutrophils (%, abs, total), lymphocytes (%), monocytes (abs, tot), ESS, coagulation time, fibrinogen, cell ratio factors (CRF) (ratio between cancer cells- CC and blood cells subpopulations), tumor size, age, tumor growth, T1-4, G1-3, PT N0---N12 (P=0.046-0.000). Neural networks computing, genetic algorithm selection and bootstrap simulation revealed relationships of PT early—invasive cancer and CRF: healthy cells/CC (rank=1), erythrocytes/CC (2), stick neutrophils/CC (3), thrombocytes/CC (4), eosinophils/CC (5), segmented neutrophils/CC (6), lymphocytes/CC (7), monocytes/CC (8), leucocytes/CC (9). Correct classification PT early—invasive cancer was 100% by neural networks computing (area under ROC curve=1.0; error=0.0). CONCLUSION: Blood cell circuit significantly influenced the phase transition early—invasive lung cancer.

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CONCLUSIONS: 5YS of local advanced ECP after combined radical procedures significantly depended on: tumor characteristics, blood cell circuit, cell ratio factors, biochemical factors, hemostasis system, anthropometric data and adjuvant treatment. Optimal strategies for local advanced ECP are: 1) availability of very experienced thoracoabdominal surgeons because of complexity radical procedures; 2) aggressive en block surgery and adequate lymph node dissection for completeness; 3) precise prediction; 4) AT for ECP with unfavorable prognos

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Conclusions: 10-Year survival of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) anthropometric data; 10) surgery type. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.

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CONCLUSIONS: 10-Year survival after radical procedures significantly depended on: 1) PT “early-invasive cancer”; 2) PT N0--N12; 3) Cell Ratio Factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) EC characteristics; 9) tumor localization; 10) anthropometric data; 11) surgery type. Optimal diagnosis and treatment strategies for EC are: 1) screening and early detection of EC; 2) availability of experienced thoracoabdominal surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for ECP with unfavorable prognosis.

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Join Dr. Muhammad Ali Rabbani, Assistant Professor of Anatomy, for an enlightening exploration of advanced concepts in the histology of connective tissue. Building upon foundational knowledge, this lecture delves into the histological features, classification, and functional significance of various types of connective tissue, providing a comprehensive understanding of their roles in maintaining tissue integrity and homeostasis. From the dynamic interplay of cells and extracellular matrix components to the clinical correlations and medical applications, embark on a journey through the intricacies of connective tissue histology with Dr. Rabbani as your guide. 🔬 Key Topics Covered: - Interstitial Fluid: Explore the composition and physiological significance of interstitial fluid in connective tissue, including its role in maintaining tissue hydration, nutrient exchange, and waste removal. - Types of Connective Tissue: Examine the diverse types of connective tissue, including connective tissue proper, embryonic connective tissue, and specialized variants, and understand their structural characteristics, cellular composition, and functional adaptations. - Histological Features: Investigate the histological features of connective tissue, ranging from loose and dense connective tissue to specialized types such as reticular and mucoid connective tissue, and comprehend their unique properties and functions. - Adipose Tissue: Gain insight into the structure, function, and histogenesis of adipose tissue, including the classification of white and brown adipose tissue, their physiological roles, and regulatory mechanisms. - Clinical Correlations: Explore the clinical relevance of connective tissue histology in health and disease, including its implications for tissue repair, inflammation, metabolic disorders, and therapeutic interventions. 🎓 Learning Objectives: By the end of this session, students will: - Describe the composition and functions of interstitial fluid in connective tissue. - Summarize the histological features and classification of various types of connective tissue. - Compare and contrast different types of connective tissue based on cellular composition, fiber arrangement, and functional adaptations. - Explain the physiological roles of adipose tissue and its significance in metabolic regulation, thermogenesis, and pathological conditions. 💡 Medical Applications: - Apply knowledge of connective tissue histology to interpret histopathological findings, diagnose connective tissue disorders, and develop targeted therapeutic strategies. - Explore research opportunities aimed at unraveling the molecular mechanisms underlying connective tissue physiology and pathology, with implications for regenerative medicine and tissue engineering. 🔍 Connect with Dr. Muhammad Ali Rabbani to deepen your understanding of advanced concepts in connective tissue histology and their clinical relevance! 🔍

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